Epigallocatechin Gallate in <i>Camellia sinensis</i> Ameliorates Skin Aging by Reducing Mitochondrial ROS Production.

ABSTRACT: Background: Reactive oxygen species (ROS) generated by mitochondrial dysfunction damage cellular organelles and contribute to skin aging. Therefore, strategies to reduce mitochondrial ROS production are considered important for alleviating skin aging, but no effective methods have been identified. Methods: In this study, we evaluated substances utilized as cosmetic ingredients and discovered Camellia sinensis (C. sinensis) as a substance that reduces mitochondrial ROS levels. Results:C. sinensis extracts were found to act as senolytics that selectively kill senescent fibroblasts containing dysfunctional mitochondria. In addition, C. sinensis extracts facilitated efficient electron transport in the mitochondrial electron transport chain (ETC)

SUBMITTER: Park JH 

PROVIDER: S-EPMC12114381 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature