Comparative Genomic Analysis of Two <i>Vibrio harveyi</i> Strains from <i>Larimichthys crocea</i> with Divergent Virulence Profiles.

ABSTRACT: Vibrio harveyi is a significant pathogen in marine aquaculture, causing vibriosis in various marine species. This study presents a comparative genomic analysis of two V. harveyi strains, N8T11 and 45T2, which exhibit differing virulence profiles. Virulence assays revealed that N8T11 caused 92% mortality in infected fish, while 45T2 resulted in 0% mortality. Whole-genome sequencing revealed that strain N8T11 harbors five plasmids (pN8T11a, pN8T11b, pN8T11c, pN8T11d and pN8T11e) absent in 45T2, encoding genes potentially linked to virulence, such as siderophore-mediated iron acquisition and stress response mechanisms. Pan-genome analysis highlighted substantial genomic plasticity within V. harveyi, with mobile genetic elements, including plasmids and prophages, contribut

SUBMITTER: Wang K 

PROVIDER: S-EPMC12114485 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature