Isolation of Ten New Sesquiterpenes and New Abietane-Type Diterpenoid with Immunosuppressive Activity from Marine Fungus <i>Eutypella</i> sp.

ABSTRACT: Background: Ten new sesquiterpenes, including eight eremophilane-type sesquiterpenes (1-8) and two compounds (9-10) with a cyclopentane ring, representing an undescribed subtype of sesquiterpene, along with a new abietane-type diterpenoid (11), were isolated and identified from a deep-sea-derived fungus: Eutypella sp. Methods: Their structures were elucidated on the basis of various spectroscopic analyses, mainly including nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HRESIMS) data, ¹³C NMR calculations with DP4+ probability analyses, electronic circular dichroism (ECD) calculations, and single-crystal X-ray diffraction experiments. Results: Furthermore, compou

SUBMITTER: Wang N 

PROVIDER: S-EPMC12114701 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature