Formulation Approaches for Optimizing Omeprazole Stability in Oral Liquid Dosage Forms.

ABSTRACT: Background/Objectives: This study aimed to evaluate the degradation of omeprazole suspension under various pH conditions and to propose recommendations for preparing compounded suspensions. Given the clinical need for alternative dosage forms for pediatric and geriatric patients and those with dysphagia, the research focused on assessing whether modifications in formulation composition-specifically the inclusion of sodium bicarbonate-could improve omeprazole stability, thus enhancing its bioavailability. Methods: Three formulations were prepared: O1, based on crushed enteric-coated pellets from a commercial product; O2, with crushed pellets suspended in an 8% sodium bicarbonate solution with glycerin; and O3, with pure omeprazole suspended in an 8% sodium bicarbonate solution

SUBMITTER: Adamiak-Giera U 

PROVIDER: S-EPMC12115015 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature