Effervescent Tablet Preparation by Twin-Screw Melt Granulation with Sorbitol as a Melt Binder.

ABSTRACT: Methods: Effervescent granules containing citric acid and sodium bicarbonate were successfully prepared for the first time via TS-MG using a polyol (sorbitol) as a melt binder. Results: Processing parameters, specifically granulation temperature and screw speed, were systematically varied to investigate their influence. The granulation efficiency, inversely related to the wt.% of fines, decreased in the following order across the tested conditions (granulation temperature-screw speed; ℃-rpm): 95-6 > 100-5 > 90-5 > 100-7 > 90-7. Granulation temperature had a minimal impact on the bulk and tapped densities of the uncalibrated granules, whereas increased screw speed led to higher densities, associated with a reduced proportion of fines. The tensile strength of the resulting effe

SUBMITTER: Horvath ZM 

PROVIDER: S-EPMC12115153 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature