Identification and Characterization of Antiviral Activity of Synthetic Compounds Against Mayaro Virus.

ABSTRACT: Background/objectives: In Brazil, the co-circulation of arboviruses-such as dengue, Zika, yellow fever, and Chikungunya viruses-creates a complex epidemiological landscape, drawing attention from health authorities due to high morbidity and mortality rates. Also present in this context is the Mayaro virus (MAYV), a neglected arbovirus, which can also cause severe syndromes and has been expanding beyond its usual endemic areas in northern and central-western Brazil. Epidemiological surveillance measures remain limited, and there are no effective prophylactic strategies or antiviral treatments for this neglected arbovirus. In this study, we evaluated the antiviral activity of commercial and synthetic compounds against MAYV using an image high-throughput screening (iHTS) system. Met

SUBMITTER: Andreolla AP 

PROVIDER: S-EPMC12115251 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature