Kinetic rates of antibody binding correlate with neutralization sensitivity of variant simian immunodeficiency virus strains.

ABSTRACT: Increasing evidence suggests that an effective AIDS vaccine will need to elicit both broadly reactive humoral and cellular immune responses. Potent and cross-reactive neutralization of simian immunodeficiency virus (SIV) and human immunodeficiency virus type 1 (HIV-1) by polyclonal and monoclonal antibodies is well documented. However, the mechanisms of antibody-mediated neutralization have not been defined. The current study was designed to determine whether the specificity and quantitative properties of antibody binding to SIV envelope proteins correlate with neutralization. Using a panel of rhesus monoclonal antibodies previously characterized for their ability to bind and neutralize variant SIVs, we compared the kinetic rates and affinity of antibody binding to soluble envelope trimers

SUBMITTER: Steckbeck JD 

PROVIDER: S-EPMC1211559 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature