Postnatal Epigenetic Alterations in Calves Persistently Infected with Bovine Viral Diarrhea Virus.

ABSTRACT: Bovine viral diarrhea virus (BVDV) is a globally prevalent pathogen causing severe detriment to the cattle industry. Vertical infection occurring before the development of the fetal adaptive immune response, before 125 days of gestation, results in an immunotolerant, persistently infected (PI) calf. It was hypothesized that epigenetic alterations observed in the splenic tissue of PI fetuses at gestational day 245 would persist into the postnatal period. White blood cell DNA from five PI and five control heifers at 4 months of age was subjected to reduced representation bisulfite sequencing and interpreted within the context of complete blood count and flow cytometry data herein. Analysis revealed 8367 differentially methylated sites contained within genes associated with the immune and car

SUBMITTER: Kincade JN 

PROVIDER: S-EPMC12115714 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature