Promotion of neuroinflammation in select hippocampal regions in a mouse model of perimenopausal Alzheimer's disease.

ABSTRACT:

Introduction

Alzheimer's disease, the most common form of dementia, is characterized by age-dependent amyloid beta (Ab) aggregation and accumulation, neuroinflammation, and cognitive deficits. Significantly, there are prominent sex differences in the risk, onset, progression, and severity of AD, as well as response to therapies, with disease burden disproportionately affecting women. Although menopause onset (i.e., perimenopause) may be a critical transition stage for AD susceptibility in women, the role of early ovarian decline in initial disease pathology, particularly key neuroinflammatory processes, is not well understood.

Methods

To study this, we developed a unique mouse model of perimenopausal AD by combining an accelerated ovarian failure (AOF) model of menopause ind

SUBMITTER: Marongiu R 

PROVIDER: S-EPMC12116374 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature