Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations.

ABSTRACT: Preclinical studies have shown that asparagine deprivation enhances T cell antitumour responses. Here we apply compassionate use of L-asparaginase, usually employed to treat blood malignancies, on patients with recurrent metastatic nasopharyngeal carcinoma. The use of L-asparaginase notably enhances immune-checkpoint blockade therapy in patients by strengthening CD8⁺T cell fitness. Our study shows that this combination is a promising avenue for clinical application and provides further mechanistic insight into how asparagine restriction rewires T cell metabolism.

SUBMITTER: Chang HC 

PROVIDER: S-EPMC12116382 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature