Unravelling the interplay: brain regional atrophy and neuropsychological function in early Alzheimer's disease.

ABSTRACT:

Objectives

The structural changes in the brain differ between normal aging and Alzheimer's dementia (AD). The results of cognitive function tests reflect structural changes in the brain in AD. This study aimed to determine the specific relationship between regional brain volume and neuropsychological subtest scores.

Methods

Ninety-three patients with definitive diagnosis of AD (confirmed by PET) were retrospectively enrolled. An automated program Quick Brain Volumetry (QBraVo) was used to measure the regional gray matter (GM) volume of the participants. Each score of the Seoul Neuropsychological Screening Battery (SNSB) subset test was statistically analyzed to observe correlations between regional brain volumes and cognitive function. Results of the SNSB subset test were co

SUBMITTER: Heo D 

PROVIDER: S-EPMC12116575 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature