Qifuyin alleviates anxiety and depression in 3×Tg-AD mice by modulating neuroendocrine function.

ABSTRACT:

Background

Alzheimer's disease (AD) is frequently accompanied by behavioral and psychological symptoms of dementia (BPSD). Studies have shown that 3×Tg-AD mice, a classical animal model of AD, exhibit anxiety and depression-like behaviors characteristic of BPSD.

Objective

This study investigated the effects of Qifuyin on anxiety and depression-like behaviors in 3×Tg-AD mice.

Methods

The 20 male and female C57BL/6 mice at 10.3 months of age were used as the control group, while the 82 male and female 3×Tg-AD mice of the same age were divided into five groups. The control and model groups were gavaged with solvent, the positive medicine group received a combination of donepezil and memantine, and the Qifuyin (QFY) groups were divided into three doses: low, medium, and h

SUBMITTER: Yu T 

PROVIDER: S-EPMC12116680 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature