Metabolic acidosis is associated with infection severity in pediatric pyelonephritis and pneumonia.

ABSTRACT:

Background

Pyelonephritis is the most common serious bacterial infection in pediatric patients. Several electrolyte abnormalities have been described with pyelonephritis, including metabolic acidosis. We sought to describe the frequency and clinical significance of metabolic acidosis in pediatric patients with acute Escherichia coli (E. coli) pyelonephritis, with comparison to parallel infection group of bacterial pneumonia.

Methods

This was a single-center, retrospective study of pediatric patients with pyelonephritis or pneumonia hospitalization. Nadir serum bicarbonate and anion gap values were collected, and baseline and recovery values when available. Serum electrolyte and creatinine values and markers of infection severity were recorded.

Results

Ninety-four pyel

SUBMITTER: Brummer H 

PROVIDER: S-EPMC12116824 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature