Design, synthesis, anticancer properties, and molecular docking of imidazolone derivatives with lipophilic moiety.

ABSTRACT: As part of an ongoing investigation into imidazolone derivatives with anticancer activities, herein we present the synthesis of a new series of imidazolones with various substituents, including lipophilic and hydrophilic. All synthesized imidazolones (3a-3g and 5a-5g) were characterized by various spectroscopic methods (¹H and ¹³C NMR, FT-IR, and mass spectrometry). The preparation was performed by condensation cyclization of vanillin-based oxazolones with various amines. The anticancer efficiencies of the prepared imidazolones were tested against four different cancer cell lines liver cancer cells (HepG2), cervical adenocarcinoma cells (HeLa), colon cancer cells (CaCo-2), breast cancer cells (MCF-7). Among the prepared imidazolones the one with dodecyl chain displaye

SUBMITTER: Fares O 

PROVIDER: S-EPMC12117022 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature