Lactobacillus rhamnosus GG maintains gut microbiota stability and promotes intestinal adaptation via activated intestinal farnesoid X receptor signaling in short bowel syndrome.

ABSTRACT: Intestinal farnesoid X receptor (FXR) signaling plays a critical role in maintaining intestinal microbiota stability. In this study, we investigated the probiotic Lactobacillus rhamnosus GG (LGG) and its ability to promote intestinal adaptation and stabilize the gut microbiota by activating intestinal FXR signaling in short bowel syndrome (SBS). In patients with type I SBS, fecal microbial α-diversity was decreased, Proteobacteria abundance was increased, and Firmicutes, Actinobacteria, and Bacteroidetes abundance levels were decreased. In vitro, LGG supernatant (LGGs) upregulated FXR expression in Caco-2 cells and ileum organoids. In vivo, LGG supplementation significantly improved intestinal morphology in wild-type (WT) SBS mice, including increased villus height, crypt depth and goblet

SUBMITTER: Gui L 

PROVIDER: S-EPMC12117158 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature