Allele-specific vitamin D receptor binding is associated with pediatric-onset multiple sclerosis.

ABSTRACT:

Background and objectives

The genetic basis of adult-onset multiple sclerosis (MS) is well-studied, but less is known about pediatric-onset MS (pedMS), comprising approximately 5% of all MS onsets. Mendelian randomization (MR) studies have demonstrated evidence for a causal association between MS and both 25-hydroxyvitamin D [25(OH)D] serum levels and genetic variation related to vitamin D receptor (VDR) binding. The objective was to identify whether VDR binding variants (VDR-BVs) previously implicated in adult-onset MS were associated with pedMS using genetic instrumental variables (GIVs).

Methods

Using previously identified VDR-BVs to construct individual GIVs with two-sample MR, we investigated associations with pedMS in 725 cases and 592 controls of European ancestry fro

SUBMITTER: Yilmaz D 

PROVIDER: S-EPMC12117238 | biostudies-literature | 2025 Apr-Jun

REPOSITORIES: biostudies-literature