Associations between ionomic profile and metabolic abnormalities in a murine model of sodium sulfide induced alopecia areata.

ABSTRACT:

Background

Alopecia areata (AA) is a common autoimmune disorder marked by non-scarring hair loss, which imposes significant psychosocial stress on patients. To investigate key metabolites and ions involved in AA's pathogenesis, we utilized gas chromatography-mass spectrometry (GC-MS) for non-targeted metabolomics and inductively coupled plasma mass spectrometry (ICP-MS) for ionomics.

Methods

A total of 36 six-week-old Kunming mice were divided into control (n = 12), an AA model (n = 12), and tofacitinib-treated groups (n = 12). A mouse model of AA was established by sodium sulfide (Na₂S) induction in both the model and treatment groups, while the treatment group (n = 12) received tofacitinib treatment at a dose of 1 mg/kg. GC-MS was used to determine the metabolic

SUBMITTER: Li L 

PROVIDER: S-EPMC12117264 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature