Active Treatment vs Expectant Management of Patent Ductus Arteriosus in Preterm Infants: A Meta-Analysis.

ABSTRACT:

Importance

Recent evidence suggests that expectant management of hemodynamically significant patent ductus arteriosus (PDA) may confer better outcomes.

Objective

To assess clinical outcomes of active treatment vs expectant management of hemodynamically significant PDA in preterm infants.

Data sources

The PubMed (MEDLINE), Embase, and Cochrane Library databases were searched for randomized clinical trials (RCTs) published between January 1, 2010, and July 31, 2024.

Study selection

RCTs were included if they enrolled preterm infants born before 33 weeks of gestation and had 2 groups comparing active treatment with expectant management.

Data extraction and synthesis

The Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement was followe

SUBMITTER: Buvaneswarran S 

PROVIDER: S-EPMC12117495 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature