Potential interactions between direct oral anticoagulants and atorvastatin/simvastatin: a cohort and case-crossover study.

ABSTRACT:

Background

Direct oral anticoagulants (DOACs) are commonly co-prescribed with statins. Although biologically plausible, whether there is a drug interaction between DOACs and atorvastatin/simvastatin is unclear.

Aim

To investigate the association between co-prescribed DOACs and atorvastatin/simvastatin and bleeding, cardiovascular disease, and mortality.

Design and setting

Cohort and case-crossover study using data from English general practices in the Clinical Practice Research Datalink Aurum from 1 January 2011 to 31 December 2019.

Method

A cohort design was used to estimate hazard ratios for clinically relevant pharmacological interaction safety outcomes (intracranial bleeding, gastrointestinal bleeding, and other bleeding) comparing DOACs and atorvastatin/si

SUBMITTER: Wong AY 

PROVIDER: S-EPMC12117505 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature