The impact of aging on achilles tendon ossification in mice.

ABSTRACT:

Background

Heterotopic ossification is a frequent complication of soft tissue injuries, particularly in tendons. Although ossification in tendon tissue has been reported in a range of aging and disease models, the underlying biomarkers and mechanisms remain unknown. And the characterisation and sensitivity of previous diagnostic biomarkers for tendon ectopic ossification do not meet the demands of clinical use. The aim of this study was to characterise the effects of aging on ossification in the mouse Achilles tendon and to identify characteristic genes and therapeutic targets for tendon ossification in mice by using a machine learning approach.

Methods

We retrieved the transcriptome profile of GSE126118 from the Gene Expression Omnibus (GEO) database. Following background c

SUBMITTER: Cai H 

PROVIDER: S-EPMC12117786 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature