Causal association of metabolic syndrome with chronic kidney disease progression: A Mendelian randomization study.

ABSTRACT: Research from the past has indicated a link between the risk of chronic kidney disease (CKD) and metabolic syndrome (MetS). It is yet unknown. Nevertheless, exactly how the dynamic process of declining renal function and metabolic syndrome are related. The study's purpose is to evaluate the causal relationship between MetS and the deterioration in kidney function using a Mendelian randomization (MR). Univariable and multivariable MR were applied to evaluate the causal relationships between MetS and its components with Rapid3, CKDi25, and CKD. The main source of MetS data was the GTC database, whose constituents came from extensive genome-wide association research. The CKDGen Consortium provided data on dynamic changes in kidney function. Preliminary analysis was conducted using five differ

SUBMITTER: Guo Q 

PROVIDER: S-EPMC12118223 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature