Extracellular Matrix-Mediated Crosslinking of Adhesive Hyaluronic Acid Patch for Treating Volumetric Muscle Injury.

ABSTRACT: The treatment of volumetric muscle loss (VML) is challenging owing to the deficiency of appropriate bioscaffolds and ineffective therapeutic outcomes with conventional approaches. Adhesive hydrogels have emerged as potential tools for promoting tissue regeneration, offering effective integration with damaged tissues. However, technical procedures requiring non-biocompatible crosslinking methods, mechanical mismatches, or the absence of tissue-specific microenvironments in conventional adhesive hydrogels have hindered their successful application in tissue reconstruction. In this study, a patch-type adhesive hydrogel is developed by combining a muscle tissue-derived extracellular matrix (MEM) and catechol-conjugated hyaluronic acid (HA-CA). This MEM-containing HA-CA (HCM) patch hydrogel uti

SUBMITTER: Jeon EJ 

PROVIDER: S-EPMC12118333 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature