Fecal microbiota transplantation from a healthy pouch donor for chronic pouchitis: a proof-of-concept study.

ABSTRACT: Chronic pouchitis is a common complication after ileal pouch-anal anastomosis (IPAA) with limited treatment options. In this case series, we aimed to investigate clinical and microbiome changes, as well as adverse events, associated with using fecal microbiota transplantation (FMT) from a donor with a normal functioning IPAA to induce remission in patients with chronic pouchitis. Methods The study was a case-series including a 4-week intervention period and 12-month follow-up. Patients with chronic pouchitis who met the inclusion criteria were recruited from the Department of Gastrointestinal Surgery at Aalborg University Hospital, Denmark. Participants received FMT derived from a donor with a normal functioning IPAA. Treatment was administered by enema daily for two weeks, then every othe

SUBMITTER: Kousgaard SJ 

PROVIDER: S-EPMC12118383 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature