Adaptations in gut Bacteroidales facilitate stable co-existence with their lytic bacteriophages.

ABSTRACT: Bacteriophages (phages) and bacteria within the gut microbiome persist in long-term stable coexistence. These interactions are driven by eco-evolutionary dynamics, where bacteria employ a variety of mechanisms to evade phage infection, while phages rely on counterstrategies to overcome these defenses. Among the most abundant phages in the gut are the crAss-like phages that infect members of the order Bacteroidales, in particular, genus Bacteroides. In this study, we explored some of the mechanisms enabling the co-existence of four phage-Bacteroidales host pairs in vitro using a multi-omics approach (transcriptomics, proteomics and metabolomics). These included three Bacteroides species paired with three crAss-like phages (Bacteroides intestinalis and фcrAss001,

SUBMITTER: Cortes-Martin A 

PROVIDER: S-EPMC12118408 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature