Epigenetic signatures of maternal-fetal health: insights from cord blood and placenta.

ABSTRACT: The placenta is vital for fetal growth, and its methylation patterns reflect placental function, affecting the fetus and providing insights into disease origins. While cord blood methylation is convenient for assessing the fetal environment, methylation profiles vary by tissue due to variance in cell populations, function, and life stage. As tissue differences extensively contribute to the DNA methylation patterns, using surrogate samples such as cord blood may result in inconsistent findings. In this study, we aim to quantify the correlation of cytosine-phosphate-guanine dinucleotides (CpGs) between paired cord blood and placenta samples. Using the Infinium Human Methylation 450 K BeadChip, we compared methylation patterns in cord blood mononuclear cells (CBMC; n = 54), the

SUBMITTER: Puvvula J 

PROVIDER: S-EPMC12118431 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature