Wound state monitoring by multiplexed, electrochemical, real-time, localized, inflammation-tracking nitric oxide sensor (MERLIN).

ABSTRACT: Nitric oxide (NO) released endogenously by induced NO synthase (iNOS) in macrophages is a key regulatory biomarker for wound inflammation. Detecting NO directly on the wound bed is challenging due to its short half-life time (6 to 50 seconds), low physiological concentration (nanomolar to micromolar), and interferences in the complex wound environment. Here, we present a compliant, multiplexed, electrochemical, real-time, localized, inflammation-tracking NO sensor (MERLIN) array for in vivo spatiotemporal measurement of NO, with high sensitivity (883 ± 283 nanoamperes per micromolar per square centimeter); selectivity against nitrites (~27,900-fold), ascorbic acid (~3800-fold), and uric acid (~6900-fold); and low limit of detection (~8.00 nM). MERLIN spatiotemporally tracked NO on rat skin

SUBMITTER: Wang L 

PROVIDER: S-EPMC12118596 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature