Manganese-based type I collagen-targeting MRI probe for in vivo imaging of liver fibrosis.

ABSTRACT: Liver fibrosis is a common pathway shared by all forms of progressive chronic liver disease. There is an unmet clinical need for noninvasive imaging tools to diagnose and stage fibrosis, which presently relies heavily on percutaneous liver biopsy. Here, we explored the feasibility of using a novel type I collagen-targeted manganese (Mn)-based MRI probe, Mn-CBP20, for liver fibrosis imaging. In vitro characterization of Mn-CBP20 demonstrated its high binding affinity for human collagen (K_d = 9.6 µM), high T₁-relaxivity (48.9 mM^-1 s^-1 at 1.4 T and 27 °C), and kinetic inertness to Mn release under forcing conditions. We demonstrated MRI using Mn-CBP20 performs comparably to previously reported gadolinium-based type I collagen-targeted probe EP-3533

SUBMITTER: Zhang C 

PROVIDER: S-EPMC12118721 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature