Repetitive transcranial magnetic stimulation increases synaptic plasticity of cortical axons in the APP/PS1 amyloidosis mouse model.

ABSTRACT:

Significance

Growing evidence highlights the therapeutic potential of repetitive transcranial magnetic stimulation (rTMS) in diseases causing dementias such as Alzheimer's disease (AD). However, individual responses to rTMS are variable, and its underlying neural mechanisms are not fully understood.

Aim

As synaptic dysfunction is one of the key mechanisms associated with cognitive deficits in dementia, we investigated the effect of rTMS on cortical synapses using an APP/PS1 amyloidosis mouse model of AD crossed with fluorescent reporters linked to the Thy-1 promoter.

Approach

Using in vivo two-photon imaging, we characterized the plasticity of excitatory terminaux (TB) and en passant (EPB) axonal boutons at 48-h intervals for 8 days on either side

SUBMITTER: Fulopova B 

PROVIDER: S-EPMC12119023 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature