Characterization of Transgenic Lines Labeling Reticulospinal Neurons in Larval Zebrafish.

ABSTRACT: From lamprey to monkeys, the organization of the descending control of locomotion is conserved across vertebrates. Reticulospinal neurons (RSNs) form a bottleneck for descending commands, receiving innervation from diencephalic and mesencephalic locomotor centers and providing locomotor drive to spinal motor circuits. Given their optical accessibility in early development, larval zebrafish offer a unique opportunity to study reticulospinal circuitry. In fish, RSNs are few, highly stereotyped, uniquely identifiable, large neurons spanning from the midbrain to the medulla. Classically labeled by tracer dye injections into the spinal cord, recent advances in genetic tools have facilitated the targeted expression of transgenes in diverse brainstem neurons of larval zebrafish. Here, we provide

SUBMITTER: Collins EMD 

PROVIDER: S-EPMC12119039 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature