Recombinant human fibronectin segment (rhFN₁₀₂₄) hydrogel carried hPDLSCs to repair diabetic trauma by activated NF-κB signaling pathway.

ABSTRACT: The accumulation of advanced glycation end products (AGEs) plays a crucial role in chronic inflammation and delayed wound healing in individuals with diabetes. In this context, fibronectin has been identified as a crucial protein that promotes the differentiation of human periodontal ligament stem cells (hPDLSCs) into myofibroblasts, which play a vital role in the repair of diabetic skin ulcers. This process is intimately associated with the integrin β1 receptor and the NF-κB signaling pathway, both crucial for cellular responses to fibronectin. To validate our hypothesis, we expressed rhFN₁₀₂₄, a recombinant protein containing the integrin β1 affinity-binding domain from human fibronectin segments 12-14. This protein was used to formulate a hydrogel for hPDLSCs. rhFN_1024</

SUBMITTER: Cong J 

PROVIDER: S-EPMC12119132 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature