Eliciting Dual-Niche Immunological Priming by Acupoint Delivery of Nanovaccines.

ABSTRACT: Immunization has long played essential roles in preventing diseases. However, the desire for precision delivery of vaccines to boost a robust immune response remains largely unmet. Here, we describe the use of acupoint delivery of nanovaccines (ADN) to elicit dual-niche immunological priming. ADN can simultaneously stimulate mast cell-assisted maturation of dendritic cells at the acupoint and enable direct delivery of nanovaccines into the draining lymph nodes. We demonstrate that ADN not only provokes antigen presentation by lymph node-resident CD8α⁺ dendritic cells, but also induces the accumulation of nanovaccines in B-cell zones, amplifying antigen-specific cytotoxic T lymphocyte responses and immunoglobulin G antibody expression in draining lymph nodes. ADN also generates s

SUBMITTER: Wang L 

PROVIDER: S-EPMC12119423 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature