Wogonin inhibits the proliferation of prolactinoma through the PI3K/AKT signaling pathway.

ABSTRACT:

Objectives

This investigation sought to explore the inhibitory impact of wogonin on prolactinoma and elucidate its underlying mechanisms through network pharmacology, molecular docking (MD), and molecular biology experiments.

Methods

Target identification for wogonin and prolactinoma was conducted using relevant databases, followed by protein-protein interaction (PPI) analysis of intersecting targets via the STRING database. Functional and pathway enrichment analyses were executed utilizing Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) methodologies. Hub genes were identified from the PPI network, and MD was utilized to assess the binding patterns and interaction strength between wogonin and hub targets. Network pharmacological findings were further v

SUBMITTER: Du Z 

PROVIDER: S-EPMC12119628 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature