Multimodal neuroimaging insights into the neurobiology of healthy aging across the lifespan.

ABSTRACT:

Purpose

The purpose of this study was to advance our understanding of the neurobiology of healthy aging, which is crucial for improving quality of life and preventing age-related diseases. Despite its importance, a comprehensive investigation of this process has yet to be fully characterized.

Methods

We used a hybrid PET/MRI scanner to assess neurophysiological parameters in 80 healthy individuals aged 20-78. Cerebral amyloid-beta (Aβ) deposition and glucose metabolism were assessed using PET scans, while participants underwent simultaneous MRI scans.

Results

We found a positive correlation between Aβ-deposition and aging, and a negative correlation between glucose metabolism and aging. The insula showed the strongest negative correlation between glucose metabolism an

SUBMITTER: Knudsen LV 

PROVIDER: S-EPMC12119650 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature