Unveiling the potential of copper-61 vs. gallium-68 for SSTR PET imaging.

ABSTRACT:

Purpose

In recent years, copper-61 has attracted considerable attention from both physicists and radiochemists due to its favorable physical decay properties for PET imaging and its ease of production at any cyclotron center producing [¹⁸F]FDG. The aim of this study was to evaluate the potential of ⁶¹Cu-based radiopharmaceuticals for PET imaging of NETs, as an alternative to the commonly used gallium-68.

Methods

Copper-61 was produced by irradiation of natural zinc liquid targets, followed by post-processing. In vitro evaluation of ⁶¹Cu- and ⁶⁸Ga-labeled SST analogues was performed in SSTR positive AR42J tumor cells. PET/MRI was carried out in mice bearing AR42J subcutaneous tumors.

Results

High molar activity [⁶¹

SUBMITTER: Fonseca AI 

PROVIDER: S-EPMC12119765 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature