The relationship between acid-sensing ion channel, ASIC2, and oncogenic β-catenin signaling in ovarian cancer.

ABSTRACT: Inflammation associated with incessant ovulation plays a key role in epithelial ovarian cancer (EOC) pathogenesis. Ion channels, such as acid-sensing ion channel-2 or ASIC2 are known to be upregulated in inflammatory conditions and may play a role in cancer cell invasion and metastasis. Previously we reported the role of phosphodiesterase 10A (PDE10) modulation of β-catenin in ovarian cancer, and are currently investigating its contribution to ovarian pathogenesis. Differential ASIC2 expression was noted with PDE10 modulation in both pre-malignant and ovarian cancer tissues. Hence, we presently report the potential role of ASIC2 in EOC development and progression as well as involvement with PDE10. ASIC2 protein is expressed across all EOC cell lines, primarily within the nucleus. Knockout

SUBMITTER: Joshi T 

PROVIDER: S-EPMC12119882 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature