CA3 bridges dietary restriction to glioblastoma suppression and tumor progression as a key downstream effector.

ABSTRACT: Dietary restriction (DR) is recognized as a health-promoting, non-pharmacological intervention with demonstrated inhibitory effects on the initiation and progression of cancer. The molecular mechanisms underpinning DR's anticancer activity are pivotal, with documented evidence of its suppressive role across a spectrum of cancers. Glioblastoma multiforme (GBM) represents an aggressively malignant intracranial neoplasm, and despite incremental therapeutic and managerial advancements, the clinical outcomes remain suboptimal. Consequently, the discovery of novel molecular markers to augment diagnostic accuracy and therapeutic efficacy is imperative. Employing an array of bioinformatics strategies, we conducted an exhaustive analysis of molecules associated with DR, culminating in the identific

SUBMITTER: Mao J 

PROVIDER: S-EPMC12119974 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature