Antiviral activity of newly synthesized pyrazole derivatives against Newcastle disease virus.

ABSTRACT: Newcastle disease virus (NDV) is a highly contagious poultry disease that affects the respiratory, nervous, and digestive systems, causing significant losses to the poultry industry. Pyrazole-based scaffolds had significant potential as antiviral agents targeting various pathogens. Thus, a series of 4-substituted pyrazole derivatives were synthesized by reacting 5-chloro-4-formyl-3-methyl-1-phenylpyrazole with some nitrogen and carbon-based nucleophiles. The antiviral efficacy of these compounds was evaluated against NDV by assessing their ability to inhibit virus-induced haemagglutination. Notably, hydrazone 6 and thiazolidinedione derivative 9 achieved complete (100%) protection against NDV with 0% mortality, while the pyrazolopyrimidine derivative 7 provided 95% protection. Additionally

SUBMITTER: El-Sewedy A 

PROVIDER: S-EPMC12119990 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature