Clinico-genomic study reveals association of dengue virus genome high frequency mutations with dengue disease severity.

ABSTRACT: Transmission of the dengue virus (DENV) places a huge burden on public health in several endemic regions. Like other RNA viruses, mutations in the DENV genome greatly governs its virulence, transmissibility, and interaction with the host immune system. Present study focuses on integrated analysis of mutation and clinical data accompanied at the onset of dengue fever. The findings from the associated clinical data with the variants of the DENV are critical for early detection of the disease and understanding the disease progression. RNA was isolated from the 1310 serum samples collected from the NS1-antigen positive dengue patients. Serotyping reveals that DENV-2 was predominant in circulation. The genome of 1305 DENV-2 was sequenced using Oxford Nanopore Technology and Illumina platforms.

SUBMITTER: Ravi V 

PROVIDER: S-EPMC12120001 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature