Elimination of certain honeybee venom activities by adipokinetic hormone.

ABSTRACT: The primary aim of this study was to analyse the influence of honeybee venom on various aspects of Drosophila melanogaster physiology and to assess the efficacy of adipokinetic hormone (AKH) in mitigating venom toxicity. We examined the harmful effects of venom on the thoracic muscles and central nervous system of Drosophila, as well as the potential use of AKH to counteract these effects. The results demonstrated that envenomation altered AKH levels in the Drosophila CNS, promoted cell metabolism, as evidenced by an increase in citrate synthase activity in muscles, and improved relative cell viability in both organs incubated in vitro. Furthermore, venom treatment reduced the activity of two key antioxidative stress enzymes, superoxide dismutase and catalase, and modified the expression o

SUBMITTER: Cerny J 

PROVIDER: S-EPMC12120068 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature