Exposure to Legacy Per- and Polyfluoroalkyl Substances from Diet and Drinking Water in California Adults, 2018-2020.

ABSTRACT: People are exposed to per- and polyfluoroalkyl substances (PFAS) through multiple sources, with diet historically considered a major source in general populations. This study characterized legacy PFAS in serum from 700 California adults and examined contributions from diet and drinking water. We applied robust regression to estimate associations between nontransformed serum PFAS concentrations, self-reported food consumption, and drinking water PFAS concentrations measured under the USEPA's third Unregulated Contaminant Monitoring Rule (2013-2015). Detectable drinking water concentrations were associated with increased serum perfluorooctanoic acid (PFOA) (0.26 ng/mL; 95% CI: 0.077, 0.43), perfluorohexanesulfonic acid (PFHxS) (0.64 ng/mL; 95% CI: 0.058, 1.23), and perfluorooctanesulfonic ac

SUBMITTER: Pennoyer EH 

PROVIDER: S-EPMC12120991 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature