Co-design of a routine clinical review to improve the safety of high dose radical cure treatment for Plasmodium vivax malaria: findings from Cambodia and Ethiopia.

ABSTRACT:

Background

Low dose primaquine regimens are widely used to treat Plasmodium vivax malaria, but they have limited efficacy and effectiveness. Short courses with higher daily doses as well as single dose tafenoquine have the potential to improve effectiveness but can increase the risk of adverse events. A clinical review visit on day 3 post-treatment initiation could facilitate adherence and improve safety, but it is unclear how it could be integrated into routine malaria care.

Methods

Between March and September 2023, focus group discussions (FGDs) with P. vivax malaria patients and healthcare providers were conducted in Cambodia and Ethiopia. In the FGDs participants co-designed a day 3 review suitable for their setting based on material infrastructure 'building blocks' (loc

SUBMITTER: Cassidy-Seyoum SA 

PROVIDER: S-EPMC12121043 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature