Juvenile hormone and BMP signaling modulate fat body cell fate during the transition of previtellogenic development to vitellogenesis.

ABSTRACT:

Background

Insect fat body, a central tissue for nutrient storage, energy metabolism, and protein synthesis, degrades by apoptosis and autophagy during larval metamorphosis. After adult emergence, the fat body grows rapidly with cell proliferation and polyploidization during the previtellogenic period but ceases cell proliferation in the vitellogenic phase. So far, the regulatory mechanisms underlying fat body cell fate decisions in adulthood remain unknown.

Results

Transcriptomic analysis of locust fat body revealed the enrichment of pathways associated with cell cycle, nuclear division, and DNA replication. Decapentaplegic (Dpp) was among the top of differentially expressed genes in the signaling cascades involved in regulating cell proliferation. Abundance of Dpp, phospho

SUBMITTER: Wu Z 

PROVIDER: S-EPMC12121051 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature