Untargeted metabolomics and transcriptomics joint analysis of the effects of polystyrene nanoplastics on lipid metabolism in the mouse liver.

ABSTRACT:

Background

Micro/nanoplastics (MNPs), as emerging environmental pollutants, are widely present in environments that are essential for human survival. They exist in vast quantities and possess stable properties, making them challenging to manage. Some reports indicated that there is a positive correlation between the production of MNPs and the incidence of obesity. The liver serves as both the central hub for lipid metabolism and a prime target for MNPs toxicity. These studies revealed that MNPs can lead to increased hepatic lipid accumulation, suggesting that they may be potential obesogens. However, the specific metabolic changes and possible mechanisms involved remain to be elucidated.

Methods

This study focuses on the impact of nanoplastics (NPs) on liver lipid metabolism

SUBMITTER: Chen L 

PROVIDER: S-EPMC12121128 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature