Single-cell RNA sequencing reveals the role of GTF2F2 in ovarian cancer oncogenesis and progression.

ABSTRACT:

Background

Ovarian cancer is one of the most common malignancies of the female reproductive system and is associated with poor prognosis. This study aimed to utilize single-cell RNA sequencing to investigate the heterogeneity of malignant epithelial cells in ovarian cancer, focusing on their potential functions and the implications for treatment and prognosis.

Methods

Single-cell RNA sequencing data were clustered using a single-cell transcriptome clustering method, and malignant epithelial cells were identified through copy number variation analysis. The interaction patterns between different malignant subpopulations and immune/stromal cells were analyzed using cell-to-cell communication analysis. A risk score (URS) model based on the UBE2C + epithelial subpopulation was th

SUBMITTER: Du H 

PROVIDER: S-EPMC12121145 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature