Unraveling lncRNA TRG-AS1: a novel biomarker for poor prognosis of gastric cancer and key to regulating malignant behaviors by targeting miR-873-5p.

ABSTRACT:

Background and study aims

To alleviate patient stress and advance gastric cancer research, this study aims to investigate the potential association between aberrant expression of TRG-AS1 and gastric cancer, and to examine its potential impact on the biological behaviors of gastric cancer cells.

Materials and methods

To find out how TRG-AS1 is expressed in the tissues and cells of gastric cancer, real-time fluorescence quantitative PCR was employed. The connection between TRG-AS1 and pathological features, as well as its prognostic importance, were examined using the Chi-square test and Cox regression analysis. The dual luciferase reporting assay was utilized to confirm the targeting of TRG-AS1 and miR-873-5p. Transwell assay and CCK-8 test were used to identify the roles tha

SUBMITTER: Hu M 

PROVIDER: S-EPMC12121179 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature