Reprogramming FGF1 from the natural growth factor to the engineered heparan sulphate biosensor.

ABSTRACT: Heparan sulphate proteoglycans (HSPGs) are cell surface and extracellular matrix proteoglycan family members, playing a key role in diverse biological activities including signal transduction or endocytosis. To date, many HSPG ligands have been identified, including growth factors interacting via sulfated domains of heparan sulphate (HS) chains. Due to significant overexpression of HSPGs in various cancers, discovering novel biomolecules capable of HSPGs recognition, which may act as HSPGs biosensors or drug carriers targeting HSPGs, is essential. Fibroblast growth factors (FGFs), mainly paracrine FGFs, are natural ligands of membrane-bound HSPGs, forming ternary signaling complex with HSPGs and fibroblast growth factor receptors (FGFRs). Here we employed the natural capability of FGF1 to

SUBMITTER: Ciura K 

PROVIDER: S-EPMC12121223 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature