Characteristics of the gut virome in patients with premalignant colorectal adenoma.

ABSTRACT:

Background

The multi-kingdom gut microbiota (e.g., bacteriome, mycobiome, and virome) characteristics of colorectal cancer have been extensively studied, yet there is still an insufficient description of the microbiota features in its early-stage, colorectal adenoma, particularly in the gut virome aspect.

Methods

Based on the Metagenomic Gut Virus catalogue (MGV) containing 54,118 non-redundant gut viral genomes, this study characterized the virome composition and diversity using publicly available metagenomic sequencing data from 419 individuals with premalignant colorectal adenoma and 552 healthy controls. Furthermore, we identified and assessed the reliability and classification performance of adenoma-associated microbial signatures through comparative analysis and the ra

SUBMITTER: Zhang P 

PROVIDER: S-EPMC12121241 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature