Vitamin D Supplementation, Chronic Obstructive Lung Disease and Asthma Exacerbations, and Lung Function Decline.

ABSTRACT:

Background

It remains unclear whether supplementation with vitamin D reduces risk of acute exacerbations of chronic obstructive lung disease (COPD) or asthma, major contributors to the world-wide burden of disease.

Objectives

To compare effects of vitamin D with placebo supplementation for the prespecified primary endpoints 1) acute exacerbations of COPD and 2) decline in pulmonary function measures of airflow obstruction. Prespecified secondary endpoints included asthma exacerbations and control.

Methods

Lung VITamin D and OmegA-3 TriaL (VITAL) is an ancillary study of VITAL, a United States nationwide, randomized, placebo-controlled trial with a 2-by-2 factorial design of vitamin D₃ (2000 IU/d) and marine n-3 fatty acids (1 g/d) among men 50 y and women 5

SUBMITTER: Gold DR 

PROVIDER: S-EPMC12121404 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature