Cholinergic and Glutamatergic Axons Differentially Require Glial Support in the Drosophila PNS.

ABSTRACT: In vertebrates, there is a differential interaction between peripheral axons and their associated glial cells. While large-caliber axons are covered by a myelin sheath, small-diameter axons are simply wrapped in Remak fibers. In peripheral nerves of Drosophila larvae, axons are covered by wrapping glial cell processes similar to vertebrate Remak fibers. Whether differences in axonal diameter influence the interaction with glial processes in Drosophila has not yet been analyzed. Likewise, it is not understood whether the modality of the neuron affects the interaction with the wrapping glia. To start to decipher the mechanisms underlying glial wrapping, we employed APEX2 labeling in larval filet preparations. This allowed us to follow individual axons of defined segmental nerves at ultrastru

SUBMITTER: Kautzmann S 

PROVIDER: S-EPMC12121464 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature