The American Transformative HIV Study: Protocol for a US National Cohort of Sexual and Gender Minority Individuals With HIV.

ABSTRACT:

Background

Sexual and gender minority (SGM) individuals represent 2%-5% of the US population, yet continue to account for more than two-thirds of new HIV infections annually.

Objective

This study seeks to identify multilevel (ie, structural, psychological, and social) and biobehavioral (ie, rectal cytokines or chemokines) determinants of amplified HIV seroconversion risk for SGM individuals, including those who use methamphetamine.

Methods

The American Transformative HIV Study is an ongoing web-based cohort study of 5364 SGM individuals from all 50 US states and Puerto Rico, enrolled in 2022 and 2023, and will be followed through 2027. We oversampled persons who use methamphetamine (2846/5364, 53.1%). We used established web-based strategies to enroll individuals aged

SUBMITTER: Grov C 

PROVIDER: S-EPMC12121540 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature